| Experiencia relevante para la docencia impartida (publicaciones, trayectoria, proyectos...) |
Ha sido investigador principal en 12 proyectos nacionales y ha colaborado en 6 proyectos en los últimos 5 años, siendo uno de ellos un Proyecto europeo (ERA-NET NEURON project, Describing pathophysiology to promote focal therapy in treatment of schizophrenia – an animal experimental study). Ha dirigido 17 TFG, 6 TFM, 1 DEA y 4 Tesis Doctorales; y actualmente está dirigiendo 2 Tesis Doctorales. Es miembro del Grupo de Fisiopatología y Farmacología del Sistema Digestivo de la Universidad Rey Juan Carlos (NEUGUT), del Comité de Ética en Experimentación Animal del HGUGM y de la Sociedad Europea de Imagen Molecular (ESMI). Ha sido revisor de trabajos cienti¿ficos a publicar en las revistas Molecular Imaging and Biology, PlosOne, BMC-Complementary and alternative medicine y Journal of Physiology and Pharmacology; revisor de trabajos a aceptar en el congreso international World Molecular Imaging Congress y evaluador externo para la ANEP (Agencia Nacional de Evaluación y Prospectiva) y de proyectos de investigación para la Croatian Science Foundation (HRZZ). Actualmente es miembro del panel editorial de la revista EC Neurology. Publicaciones de los últimos 5 años: - Scientific paper. D Romero-Miguel, M Casquero-Veiga, …, ML Soto-Montenegro. (CA) (11/11). N-acetylcysteine during periadolescence or gestation as a preventive strategy for schizophrenia in a maternal immune stimulation animal model. Translational Psychiatry 2024, jan 8;14. doi: 10.1038/s41398-023-02652-7. Q1, D1.
- Scientific paper. THC improves behavioural schizophrenia-like deficits that CBD fails to overcome: a comprehensive multilevel approach using the Poly I:C maternal immune activation. N Lamanna-Rama, D Romero-Miguel, M Casquero-Veiga, …, ML Soto-Montenegro. (CA) (10/10). Pychiatry Research 2024 Jan; 331:115643. doi: 10.1016/j.psychres.2023.115643.
- Scientific paper. J Orihuel, R Capellán, M Casquero-Veiga, ML Soto-Montenegro,…, A Higuera-Matas. (4/12). The long-term effects of adolescent Δ9-tetrahydrocannabinol on brain structure and function assessed through neuroimaging techniques in male and female rats. Eur Neuropsychopharmacol. 2023 Jun 3;74:47-63.
- Scientific paper. H Edemann-Callesen, N Bernhardt,…., ML Soto-Montenegro, C Winter, R Hadar. (10/12). Supplement treatment with NAC and Omega-3 during pregnancy partially prevents schizophrenia-related outcomes in the poly I:C rat model. Antioxidants 2023. May 9;12(5):1068. Q1
- Scientific paper. D Romero-Miguel, M Casquero-Veiga, …., ML Soto-Montenegro. (CA) (9/9). Maternal supplementation with N-acetylcysteine modulates the microbiota-gut-brain axis in offspring of the Poly I:C rat model of schizophrenia. Antioxidants 2023 Apr 20;12(4):970. Q1
- Scientific paper. R Capellán, J Orihuel, A Marcos, …, A Higuera-Matas. (7/14). Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome. Translational Psychiatry, 2023 Mar 8;13(1):84. Q1
- Scientific paper. N Lamanna-Rama, K MacDowell, …, ML Soto-Montenegro. (CA) (6/6). Neuroimaging revealed long-lasting glucose metabolism changes to morphine self-administration withdrawal in rats pretreated with the synthetic cannabinoid CP-55,940 during periadolescence. Eur Neuropsychopharmacol. 2023 Feb 11;69:60-76. Q1
- Scientific paper. M Casquero-Veiga, N Lamanna-Rama, D Romero-Miguel, …, ML Soto-Montenegro. (CA) (8/8). The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats. Front Behav Neurosci. 2023 Jan 6;16:1022622. PMID: 36733452. Q1
- Scientific paper. C Gálvez-Robleño, Y López-Tofiño, …, ML Soto-Montenegro, R Abalo. (5/6). Radiographic assessment of the impact of sex and the circadian rhythm-dependent behaviour on gastrointestinal transit in the rat. Lab Animal. 2022 Oct 26:236772221124381. D1, Q1
- Scientific paper. JA Garcia-Partida; S Torres-Sánchez; KS MacDowell;…., Soto-Montenegro; E Berrocoso. (7/11). 2022. The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia. Front Pharmacol. 13, pp.886514. Q1
- Scientific paper. M Casquero-Veiga, N Lamanna-Rama, D Romero-Miguel, M Desco, ML Soto-Montenegro (CA) (5/5). In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats. J Vis Exp. 2022 Mar 23:(181).
- Scientific paper. A Belenguer-Llorens; C Sevilla-Salcedo; M Desco; ML Soto-Montenegro (CA); V Gomez-Verdejo. (4/5). 2022. A novel Bayesian linear regression model for the analysis of neuroimaging data. Applied Sciences. 12, pp.2571.
- Scientific paper. ML Soto-Montenegro*, V García, G López-Montoya, …, E Ambrosio*. (*CA) (6/6). Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains. Scientific Reports 2022 Mar 17;12(1):4643. Q1
- Scientific paper. N Lamanna-Rama, D Romero-Miguel, M Desco, ML Soto-Montenegro. (CA). An Update on the Exploratory Use of Curcumin in Neuropsychiatric Disorders. Antioxidants 2022, 11, 353. Q1
- Scientific paper. D Romero-Miguel, M Casquero-Veiga, …, ML Soto-Montenegro. (CA) (11/11). A characterization of the effects of minocycline treatment during, adolescence on structural, metabolic and oxidative stress parameters in a maternal immune stimulation model of neurodevelopmental brain disorders Int Journal of Neuropsychopharmacology 2021, Sep 21;24(9):734-748.Q1
- Scientific paper. L Perez-Caballero, ML Soto-Montenegro, M Desco, JA Mico, E Berrocoso (2/5). Sustained escitalopram administration affects glucose metabolism in the rat brain. Eur Neuropsychopharmacol. 2021 Oct:51:1-6.
- Scientific paper. S Tosi, L Bardia, MJ Barallobre, A Muñoz-Barrutia, ML Soto-Montenegro, J Colombelli (5/6). MosaicExplorerJ: Interactive stitching of terabyte-size tiled datasets from lightsheet microscopy. 1000Res. 2020 Nov 10:9:1308.
- Scientific paper. M Casquero-Veiga, D Romero-Miguel, KS MacDowell, …, ML Soto-Montenegro. (CA) (13/13). Omega-3 fatty acids during adolescence prevent schizophrenia-related behavioral deficits: neurophysiological evidences from the prenatal viral infection with PolyI:C. European Neuropsychopharmacology 2021. Mar 15;46:14-27. Q1
- Scientific paper. M Casquero-Veiga, C Bueno-Fernandez, D Romero-Miguel, N Lamanna-Rama, J Nacher, Ml Desco, ML Soto-Montenegro (CA) (7/7). Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity. Scientific Reports 2021 Mar 10;11(1):5580.
- Scientific paper. D Romero-Miguel, N Lamanna-Rama, M Casquero-Veiga, V Gómez-Rangel, M Desco, ML Soto-Montenegro. (CA) (6/6). Minocycline in neurodegenerative and psychiatric diseases: an update. European Journal of Neurology, 2021.28(3):1056-1081. D1
- Book chapter. D Romero-Miguel, N Lamanna-Rama, M Casquero-Veiga, V Gómez-Rangel, ML Soto-Montenegro. (CA) (6/6). Positron emission tomography of the reward system. Marc Fakhoury (ed.), The brain reward system, publicado en Neuromethods, vol165: 281-305. https://doi.org/10.1007/978-1-0716-1146-3_14.
- Scientific paper. Casquero-Veiga M, García-García D, KS MacDowell, L Pérez-Caballero, S Torres-Sánchez, D Fraguas, E Berrocoso, JC Leza, C Arango, M Desco M, Soto-Montenegro ML (CA) (11/11). Risperidone administered during adolescence induced metabolic, anatomical and inflammatory/oxidative changes in adult brain: a PET and MRI study in the maternal immune stimulation animal model. European Neuropsychopharmacology 2019, Jul; 29(7):880-896.
- Scientific paper. E Gondard, ML Soto-Montenegro, A Cassol, AM Lozano, C Hamani (2/5). Transcranial direct current stimulation does not improve memory deficits or alter pathological hallmarks in a rodent model of Alzheimer's disease. J Psychiatr Res. 2019 Jul:114:93-98
- Scientific paper. Casquero-Veiga M, García-García D, Desco M, Soto-Montenegro ML (CA) (4/4). Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect. Biomed Res Int. 2018 Oct 17;2018:8560232.
- Scientific paper. Casquero-Veiga M, García-García D, Pascau J, Desco M, Soto-Montenegro ML (CA) (5/5). Stimulating the nucleus accumbens in obesity: A positron emission tomography study after deep brain stimulation in a rodent model. PlosOne 2018 Sep 27;13(9):e0204740.
- Scientific paper. Perez-Caballero L, Soto-Montenegro ML, Hidalgo-Figueroa M, Mico JA, Desco M, Berrocoso E. Deep brain stimulation electrode insertion and depression: Patterns of activity and modulation by analgesics. Brain Stimul. 2018 Jul 9.
- Scientific paper. Cal-Gonzalez J, Vaquero J, Herraiz JL, Pérez-Liva M, Soto-Montenegro ML, Peña-Zalbidea S, Desco M, Udías JM. Improving PET Quantification of Small Animal [68Ga]DOTA-Labeled PET/CT Studies by Using a CT-Based Positron Range Correction. Mol Imaging Biol. 2018 Jan 19.
- Scientific paper. R Hadar, L Bikovsky, ML Soto-Montenegro, J Schimke, P Maier, S Ewing, M Voget, F Wieske, T Götz, M Desco, C Hamani, J Pascau, I Weiner, C Winter (3/14). Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia. Mol Psychiatry. 2018 Apr 4.
Proyectos de I+D (nacionales e internacionales) a. Como investigador principal - Cannabidiol (CBD) against COVID-19 in an animal model of addiction. Plan Nacional sobre Drogas 2021. 2023-2026. EXP2022/008917
- New nanotechnological tools in the treatment of neuroinflammatory pathology and its interaction with the gut-brain axis. Proyectos de Generación de Conocimiento 2021, MICIN, PID2021-128862OB-I00.
- Cannabidiol as a preventive strategy in the onset of psychosis. Delegación del gobierno para el Plan Nacional sobre Drogas 2017 2018-2022. PNSD2017-085
- Is it possible to prevent the risk of onset of schizophrenia during pregnancy? Study in an animal model of schizophrenia. PI17/01766. Ministerio de Economía, Industria y Competitividad. 2018-2022.
- Physical exercise and N-acetylcysteine as preventive strategies during adolescence in the onset of schizophrenia: preclinical imaging and behavioral studies. Fundación Alicia Koplowitz 2016-2018.
- Deep brain stimulation (DBS) in obesity: preclinical study in two animal models. Fundación Mapfre 2016-2017.
- Preventive therapies in the onset of schizophrenia: In vivo imaging (PET and MRI) and behavioral studies. PI14/00860. Ministerio de Economía y Competitividad. 2015-2018.
- Prenatal immune challenge is an environmental risk factor for brain changes relevant to schizophrenia: Evidence from PET and MRI in a rat model for schizophrenia. Proy. intramural del CIBERSAM 2013-2014.
- OBESITY: Treatment by deep brain stimulation in an experimental model. Fundación Mapfre 2013-2014.
- Molecular PET/CT imaging of meningiomas with Ga-68-labelled peptides in a murine model. PI11/00616. Ministerio de Ciencia e Innovación. 2012-14.
- Brain effects of morphine self-administration in adult rats that have been pre-exposed to cannabis during adolescence: experimental study using in vivo imaging techniques (PET/CT and MRI). CP08/00017. Ministerio de Ciencia e Innovación. 2009 - 2012.
- In vivo monitoring of brain damage caused by ecstasy and methamphetamine, using different high-resolution imaging techniques (PET, SPECT and MRI). Fundación de Investigación Médica Mutua Madrileña. 2008 – 2011.
b. Como colaborador (en los últimos 5 años) - Salud Mental. CIBER CB07/09/0031 (Ministerio de Sanidad y Consumo). 2007 - actualidad.
- Describing pathophysiology to promote focal therapy in treatment of schizophrenia – an animal experimental study. European Research Projects on Mental Disorders (ERA-NET-NEURON). 2011-2015.
- Advanced multimodal medical imaging in real time. S2009DPI-1802 (ARTEMIS). Comunidad de Madrid. 2010-2013.
- The microbiome as a target for precision medicine. A frontier exploration from established to innovative indications. PIE16/00055. Ministerio de Economía, Industria y Competitividad, 2017-2019.
- Medical and Health Technology Innovation Platform (ITEMAS). PT13/0006/0001. Ministerio de Economía y Competitividad, 2014-2018.
- Development of a gene therapy platform for genetic kidney diseases. RTC-2017-6600-1. Ministerio de Ciencia, Innovación y Universidades. 2018-2021.
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