Universidad Nacional de Educación a Distancia

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Universidad Nacional de Educación a Distancia - UNED

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DIONISIA SANZ DEL CASTILLO

CATEDRÁTICA DE UNIVERSIDAD

QUÍMICA ORGÁNICA Y BIO-ORGÁNICA

FACULTAD DE CIENCIAS

dsanz@ccia.uned.es

(+34) 91398-7331

Academic Information

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Academic positions held

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Research activity

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Professional experience

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Research

INVESTIGATION GROUPS

  • Sistemas Supramoleculares Bioorgánicos Compuestos heterocíclicos: síntesis, propiedades multifuncionales, complejos metal-orgánicos Estructura y dinámica de biomoléculas en estado sólido. Química supramolecular. Reconocimiento molecular. Interacciones no covalentes y enlace de hidrógeno. Resonancia magnética nuclear en disolución y estado sólido. Diseño, síntesis y estudio de fármacos. Nuevos materiales orgánicos y sus aplicaciones. Química sostenible. + info
  • SEGUNDO GRUPO DE INVESTIGACIÓN Intentar seguir la misma línea en la descripción de todos los grupos

PROYECTOS DE INVESTIGACIÓN

  • Identificación de nuevos quimiotipos con propiedades antioxidantes: síntesis y aplicaciones en diferentes patologías. MINECO-CTQ2014-56833-R Investigadora Principal: R. M. Claramunt Vallespí y Dionisia Sanz Identificación de nuevos quimiotipos con propiedades antioxidantes: síntesis y aplicaciones en diferentes patologías. MINECO-CTQ2014-56833-R Investigadora Principal: R. M. Claramunt Vallespí y Dionisia Sanz
  • El enlace de hidrógeno y su influencia en la estructura de los cristales y los complejos anfitrión-huésped. MCINN-CTQ2010-16122 Investigadora Principal: R. M. Claramunt Vallespí El enlace de hidrógeno y su influencia en la estructura de los cristales y los complejos anfitrión-huésped. MCINN-CTQ2010-16122 Investigadora Principal: R. M. Claramunt Vallespí
  • Reconocimiento molecular. Aplicaciones a sistemas bioorgánicos y al desarrollo de inhibidores NOS. MEC-CTQ2007-62113/BQU Investigadora Principal: R. M. Claramunt Vallespí Reconocimiento molecular. Aplicaciones a sistemas bioorgánicos y al desarrollo de inhibidores NOS. MEC-CTQ2007-62113/BQU Investigadora Principal: R. M. Claramunt Vallespí
  • Measurement of intermolecular spin-spin coupling constants across hydrogen bonds in crystals. Proyecto del EU-NMR Infrastructure Action (026145)-Seventh Framework Programme (FP7) Responsable propuesta en Francia: Lyndon Emsley Responsable propuesta en España: R. M. Claramunt Vallespí Measurement of intermolecular spin-spin coupling constants across hydrogen bonds in crystals. Proyecto del EU-NMR Infrastructure Action (026145)-Seventh Framework Programme (FP7) Responsable propuesta en Francia: Lyndon Emsley Responsable propuesta en España: R. M. Claramunt Vallespí

Publications

  • PUBLICATIONS IN MAGAZINES R. Aggarwal, M. Hooda, N. Jain, D. Sanz, R. M. Claramunt, B. Twamley, I. Rozas. “An efficient, one-pot, regioselective synthesis of 2-aryl/hetaryl-4-methyl-5-acylthiazoles under solvent-free conditions”. J. Sulf. Chem. 1-10 (2021). DOI: 10.1080/17415993.2021.1975119

    I. Alkorta, R. M. Claramunt, D. Sanz, J. Elguero, W. Holzer. “A 13C chemical shifts study of iodopyrazoles: experimental results and relativistic and non-relativistic calculations”. Struct. Chem. 32, 925-937 (2021).  https://doi.org/10.1007/s11224-021-01755-5

    M. Marín-Luna, R. M. Claramunt, C. López, M. Pérez-Torralba, D. Sanz, F. Reviriego, I.  Alkorta, J. Elguero. “A GIPAW versus GIAO-ZORA-SO study of 13C and 15N CPMAS NMR chemical shifts of aromatic and heterocyclic bromo derivatives”. Solid State Nucl. Magn. Reson.108, (2020), https://doi.org/10.1016/j.ssnmr.2020.101676

    R. Aggarwal, S. Sharma, M. Hooda, D. Sanz, R. M. Claramunt, B. Twamley, Brendan, I. Rozas. “Visible-light mediated regioselective approach towards synthesis of 7-aroyl-6-methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine”. Tetrahedron, 75, 130728, (2019) https://doi.org/10.1016/j.tet.2019.130728

    V. Silva, A. Silva, R. M. Claramunt, C. López, D. Sanz, L. Infantes, A. Martínez López, F. Reviriego, I. Alkorta, J. Elguero. “New Tetrakis(1H-pyrazol-1-yl)methanes”. Tetrahedron, 75, 130690, (2019), https://doi.org/10.1016/j.tet.2019.130690

    Holzer, L. Castoldi, V. Kyselova, D. Sanz, R. M. Claramunt, M. C. Torralba, I. Alkorta, J. Elguero. “Multinuclear NMR spectra and GIAO/DFT calculations of N-benzylazoles and N-benzylbenzazoles”. Struct. Chem. 30, 1729-1735 (2019), https://doi.org/10.1007/s11224-019-01310-3

    V. L. M. Silva, A. M. S. Silva, R. M. Claramunt, D. Sanz, L. Infantes, Á. Martínez López, F. Reviriego, I. Alkorta, J. Elguero. “An example of polynomial expansion: the reaction of 3(5)-methyl-1H-pyrazole with chloroform and characterization of the four isomers”. Molecules 24, 568 (2019).  https://doi.org/10.3390/molecules24030568

    C. I. Nieto, M. P. Cornago, M. P. Cabildo, D. Sanz, R. M. Claramunt, M. C. Torralba, J. Elguero. “Synthesis, structure and NMR study of fluorinated isoxazoles derived from hemi-curcuminoids”. J. Fluorine Chem. 219, 39-49 (2019), https://doi.org/10.1016/j.jfluchem.2018.12.012

    C. I. Nieto, M. P. Cornago, M. P. Cabildo, D. Sanz, R. M. Claramunt, M. C. Torralba, M. R. Torres, D. Martínez Casanova, Y. Sánchez-Alegre, E. Escudero, J. L. Lavandera. “Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1, 3-Diketones”. Molecules 23, 1837 (2018), https://doi.org/10.3390/molecules23081837

    D. Sanz, R.M. Claramunt, C. Roussel, I. Alkorta, J. Elguero. “The Structure of N-Benzylazoles from Pyrrole to Carbazole: Geometries and Energies”. Indian J. Heter. Chem. 28, 1-10 (2018)

    L. Infantes, J. M. Moreno, R. M. Claramunt, D. Sanz, I. Alkorta, J. Elguero. “The structure of four thallium tris (1H-pyrazol-1-yl) hydroborates in the solid state by X-ray crystallography and in solution by NMR and DFT-GIAO calculations”. Inorg. Chim. Acta 483, 402-410 (2018), https://doi.org/10.1016/j.ica.2018.08.009
     
    M. P. Torralba, D. Sanz, R. M. Claramunt, I. Alkorta, C. Dardonville, J. Elguero. “The structure of fosfomycin salts in solution and in the solid state by nuclear magnetic resonance spectroscopy and DFT calculations”. Tetrahedron, 74, 3937-3942 (2018), https://doi.org/10.1016/j.tet.2018.02.041

    G. Sumran, R. Aggarwal, M. Hooda, D. Sanz, R. M. Claramunt. “Unusual Synthesis of Azines and Their Oxidative Degradation to Carboxylic Acid Using Iodobenzene Diacetate”. Synt. Commun.  48, 439-446 (2018),  https://doi.org/10.1080/00397911.2017.1407791

    C. I. Nieto, D. Sanz, Rosa M. Claramunt, M. C. Torralba, M. R. Torres, I. Alkorta, J. Elguero. “Molecular structure in the solid state by X-ray crystallography and SSNMR and in solution by NMR of two 1,4-diazepines”. J. Mol. Struct. 1155, 205-214 (2018), https://doi.org/10.1016/j.molstruc.2017.10.112

    C. I. Nieto, A. Andrade, D. Sanz, R. M. Claramunt, M. C. Torralba, M. R. Torres, I. Alkorta, J. Elguero. “Curcumin Related 1,4-Diazepines: Regioselective Synthesis, Structure Analysis, Tautomerism, NMR Spectroscopy, X-rayCrystallography, Density Functional Theory and GIAO Calculations”. ChemistrySelect, 2, 3732 – 3738 (2017),  https://doi.org/10.1002/slct.201700405

    R. M. Claramunt, C. I. Nieto, D. Sanz, J. Elguero. “Curcumin derived pyrazoles and related compounds”. Afinidad, LXXIV, 576, 259-268 (2016)
    L. Infantes, R. M. Claramunt, D. Sanz, I. Alkorta, J. Elguero. “The structure of two scorpionates: thallium tetrakis(3-phenyl-1H-pyrazol-1-yl)borate and potassium tetrakis(3-cyclopropyl-1H- pyrazol-1-yl)borate”. Acta Cryst. Section C, C72, 1- 7, (2016), https://doi.org/10.1107/S2053229616007385

    M. L. Jimeno, M. T. Benito, E. García Doyagüez, R. M. Claramunt, D. Sanz, M. Marín-Luna, I. Alkorta, J. Elguero. “A theoretical and experimental NMR study of BODIPY 493/503: difluoro{2-[1-(3,5-dimethyl-2H-pyrrol-2-ylidene-N)ethyl]-3,5-dimethyl-1 H -pyrrolato- N }boron”. Magn. Reson. Chem. 54, 684-688 (2016), https://doi.org/10.1002/mrc.4438

    R. Aggarwal, G. Singh, D. Sanz, R. M. Claramunt, M. C. Torralba, M. R. Torres. “NBS mediated one-pot regioselective synthesis of 2,3-disubstituted imidazo[1,2-a]pyridines and their unambiguous characterization through 2D NMR and X-ray crystallography”. Tetrahedron, 72, 3832-3838 (2016)  https://doi.org/10.1016/j.tet.2016.04.072

    C. I. Nieto, P. Cabildo, R. M. Claramunt, P. Cornago, D. Sanz, M. C. Torralba, M. R. Torres, M. B. Ferraro, I. Alkorta, M. Marín-Luna, J. Elguero. “The structure of β-diketones related to curcumin determined by X-ray crystallography, NMR (solution and solid state) and theoretical calculations”. Struct. Chem., 27, 705-730 (2016), http://dx.doi.org/10.1007/s11224-015-0704-7

    J. González-Albadalejo, D. Sanz, R. M. Claramunt, J. L. Lavandera, I. Alkorta, J. Elguero. “Curcumin and curcuminoids: chemistry, structural studies and biological properties”. An. Real. Acad. Farm. 81, 278-310 (2015).

    C. I. Nieto, M. P. Cabildo, M. P. Cornago, D. Sanz, R. M. Claramunt, M. C. Torralba, M. R. Torres, J. Elguero, J. A. García, A. López, D. Acuña-Castroviejo. “Fluorination effects on NOS inhibitory activity of pyrazoles related to curcumin”. Molecules, 20, 15643-15665 (2015), https://doi.org/10.3390/molecules200915643

    C. I. Nieto, M. P. Cabildo, M. P. Cornago, D. Sanz, R. M. Claramunt, I. Alkorta, J. Elguero, J. A. García, A. López, D. Acuña-Castroviejo. “Synthesis, structure and biological activity of 3(5)-trifluoromethyl-1H-pyrazoles derived from hemicurcuminoids”. J. Mol. Struct., 1100, 518-529 (2015), https://doi.org/10.1016/j.molstruc.2015.07.055

    D. Sanz, C. Nieto, R. M. Claramunt, I. Alkorta, J. Elguero. “A multinuclear magnetic resonance study of fluoro derivatives of hydroxybenzaldehydes”. Magn. Reson. Chem., 15, 624-631 (2015), https://doi.org/10.1002/mrc.4260

    D. Sanz, R. M. Claramunt, I. Alkorta, J. Elguero. “A theoretical and experimental NMR study of the prototropic tautomerism of tris(tetrabutylammonium) hydrogen pyrophosphate salt in solution and in the solid state”. Afinidad, 72, 14-20 (2015)

    R. Aggarwal, V. Kumar, G. Singh, D. Sanz, R. M. Claramunt, I. Alkorta, G. Sánchez-Sanz, J. Elguero. “An NMR and Computational Study of Azolo[a]pyrimidines with Special Emphasis on Pyrazolo[1,5-a]pyrimidines”. J. Heterocycl. Chem., 52, 336-345 (2015),  https://doi.org/10.1002/jhet.1955

    R. M. Claramunt, C. López, D. Sanz, J. Elguero. “Mechano Heterocyclic Chemistry: Grinding and Ball Mills”. Adv. Heterocycl. Chem., 112, 117-143 (2014), https://doi.org/10.1016/B978-0-12-800171-4.00003-2
    R. Aggarwal, V. Kumar, D. Sanz, R. M. Claramunt. “Effect of substituents on the regioselectivity of the reaction of α-tosyloxyketones with thioureas in acidic medium: Access to 2-aminothiazoles and 2-imino-2,3-dihydrothiazoles”. J. Heterocycl. Chem., 51, 598-603 (2014),  https://doi.org/10.1002/jhet.1676

    C. P. Frizzo, M. A. Villetti, A. Z. Tier, I. M. Gindri, L. Buriol, F. A. Rosa, R. M. Claramunt, D. Sanz, M.  A. P. Martins. “Structural and Thermodynamic Properties of New Pyrazolo[3,4-d]pyridazinone”. Thermochimica Acta, 574, 63-72, (2013), https://doi.org/10.1016/j.tca.2013.08.017

    D. Sanz, R. M. Claramunt, F. Mathey, I. Alkorta, G. Sánchez-Sanz, J. Elguero. “Intermolecular spin-spin coupling constants between 31P atoms”. C. R. Chimie, 16, 937-944 (2013), https://doi.org/10.1016/j.crci.2013.05.016

    P. Cornago, P. Cabildo, D. Sanz, R. M. Claramunt, M. C. Torralba, M. R. Torres, J. Elguero. “Structure in the Solid State and in Solution of Hemi-curcuminoids”. Eur. J. Org. Chem., 6043-6054 (2013), https://doi.org/10.1002/ejoc.201300488

    J. Pinto, V. L. M. Silva, A. M. S. Silva, R. M. Claramunt, D. Sanz, M. C. Torralba, M. R. Torres, F. Reviriego, I. Alkorta, J. Elguero. “The structure of azines derived from C-formyl-1H-imidazoles in solution and in the solid state: tautomerism, configurational and conformational studies”. Magn. Reson. Chem. 51, 203-221 (2013), https://doi.org/10.1002/mrc.3926

    J. Elguero, I. Alkorta, R. M. Claramunt, P. Cabildo, P. Cornago, M. A. Farrán, M. A. García, C. López, M. Pérez-Torralba, D. Santa María, D. Sanz. “The structure of NH-benzazoles(1H-benzimidazoles, 1H- and 2H-indazoles, 1H- and 2H-benzotriazoles)”. Chem. Heterocycl. Comp. 49, 177- 202, (2013), 10.1007/s10593-013-1237-x

    R. Aggarwal, V. Kumar, A. Bansal, D. Sanz, R. M. Claramunt. “Multi-component solvent-free versus stepwise solvent mediated reactions: Regiospecific formation of 6-trifluoromethyl and 4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridines”. J. Fluorine Chem., 140, 31- 37, (2012). 10.1016/j.jfluchem.2012.04.007

    P. López-Tarifa, G. Sánchez-Sanz, I. Alkorta, J. Elguero, D. Sanz, A. Perona, R. M. Claramunt, J. Elguero. “The tautomeric structures of 3(5),3’(5’)-azopyrazole [(E)-1,2-di(1H-pyrazol-3(5)-yl)diazene)]: The combined use of NMR and electronic spectroscopies with DFT calculations”. J. Mol. Struc., 1015, 138-146, (2012). 10.1016/j.molstruc.2012.02.013

    D. Sanz, R. M. Claramunt, I. Alkorta, G. Sánchez-Sanz, J. Elguero. “The structure of Glibenclamide in the solid state”. Magn. Reson. Chem., 50, 246-255, (2012). https://doi.org/10.1002/mrc.2868

    D. Sanz, R. M. Claramunt, M. A. García, I. Alkorta, J. Elguero. “A 13C and 15N experimental NMR and theoretical study of the structure of linear primary aliphatic amines and ammonium salts: from C1 to C18”. Tetrahedron, 67, 4633-4639, (2011). 10.1016/j.tet.2011.04.067

    I. Alkorta, J. Elguero, R. M. Claramunt, C. López, D. Sanz. “A theoretical multinuclear NMR study of pyrazolylborates”. Heterocycl. Commun., 16, 261-268, (2010). 10.1515/HC.2010.008
    C. P. Frizzo, M. A. P. Martins, M. R. B. Marzari, P. T. Campos, R. M. Claramunt, M. A. García, D. Sanz, I. Alkorta, J. Elguero. “Structural Studies of 2-Methyl-7-substituted Pyrazolo[1,5-a]pyrimidines”. J. Heterocycl. Chem., 47, 1259-1268. (2010), https://doi.org/10.1002/jhet.377

    R. M. Claramunt, M. Pérez-Torralba, D. Santa María, D. Sanz, B. Elena, I. Alkorta, J. Elguero. “15N-15N spin-spin coupling constants through intermolecular hydrogen bonds in the solid state”. J. Magn. Reson., 206, 274-279, (2010). 10.1016/j.jmr.2010.07.015

    D. Sanz, R. M. Claramunt, I. Alkorta, J. Elguero. “The solid-state structure of primary fatty amines: True amines or ammonium amides?”. J. Mol. Struct., 969, 106-110, (2010). 10.1016/j.molstruc.2010.01.049

    D. Sanz, A. Perona, R. M. Claramunt, E. Pinilla, M. R. Torres, J. Elguero. “Protonation effects on the chemical shifts of Schiff bases derived from 3-hydroxypyridin-4-carbaldehide”. Arkivoc, iii, 102-113, (2010). http://dx.doi.org/10.3998/ark.5550190.0011.310

     
  • PUBLICATIONS IN MAGAZINES ORCID
  • PUBLICATIONS AT CONFERENCES AUTHORS: ROCÍO MUÑOZ MANSILLA, JOAQUÍN ARANDA, JOSÉ MANUEL DÍAZ, DICTINO CHAOS, ANTONIO J. REINOSO. TITLE: Design of a dynamic positioning system for a moored floating platform using QFT robust control. TYPE OF PARTICIPATION: CONGRESS PRESENTATION: The 7th IEEE Conference on Industrial Electronics and Applications (ICIEA 2012). PUBLICATION: IEEE Conference Publications. 2012, Page (s): 763 - 768. DOI: 10.1109 / ICIEA.2012.6360827 VENUE: Singapore. Issn 978-1-4577-2117-5 YEAR: 2012


    AUTHORS: Rocío Muñoz Mansilla, Ana M. Marcos del Cano, Jesús Gómez Garzás, Isabel Martín de Llano TITLE: A study case of internet voting for the University's Senate in the National Distance Education University of Spain (UNED) Type of Presentation CONGRESS: 12th European Conference on eGovernment– ECEG 2012 Organizing entity: Institute of Public Governance and Management ESADE - Ramón Llull University. ACI International Academic Conference. CHARACTER: International PUBLICATION: Academic Publishing International ISBN 978-1-908272-41-6. Volume II, p. 511-521. PLACE: Barcelona, ​​Dates: June 13-15, 2012 YEAR 2012
  • PUBLICATIONS AT CONFERENCES AUTHORS: ROCÍO MUÑOZ MANSILLA, JOAQUÍN ARANDA, JOSÉ MANUEL DÍAZ, DICTINO CHAOS, ANTONIO J. REINOSO. TITLE: Design of a dynamic positioning system for a moored floating platform using QFT robust control. TYPE OF PARTICIPATION: CONGRESS PRESENTATION: The 7th IEEE Conference on Industrial Electronics and Applications (ICIEA 2012). PUBLICATION: IEEE Conference Publications. 2012, Page (s): 763 - 768. DOI: 10.1109 / ICIEA.2012.6360827 VENUE: Singapore. Issn 978-1-4577-2117-5 YEAR: 2012


    AUTHORS: Rocío Muñoz Mansilla, Ana M. Marcos del Cano, Jesús Gómez Garzás, Isabel Martín de Llano TITLE: A study case of internet voting for the University's Senate in the National Distance Education University of Spain (UNED) Type of Presentation CONGRESS: 12th European Conference on eGovernment– ECEG 2012 Organizing entity: Institute of Public Governance and Management ESADE - Ramón Llull University. ACI International Academic Conference. CHARACTER: International PUBLICATION: Academic Publishing International ISBN 978-1-908272-41-6. Volume II, p. 511-521. PLACE: Barcelona, ​​Dates: June 13-15, 2012 YEAR 2012
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Experience in educational, scientific and technological management and administration

He sido Secretaria y Directora del Departamento de Química Orgánica y Bio-Orgánica.